Mark Ghobrial, M.D.
Chief: Liver Transplant Program
The Methodist Hospital
Houston, Texas

This Sunday evening, Dr. Ghobrial will join Dr. Galati again to discuss several current topics regarding transplantation. There was a recent article in the New England Journal of Medicine that discussed organ donation and the donor risks that could be transmitted to the person receiving this higher than usual risk donor. The article can be downloaded here for those interested in reading further.

The Methodist Center for Liver Disease and Transplantation brings together highly trained and experienced physicians, state-of-the-art technology, and a comprehensive, multi-disciplinary approach to the treatment of liver diseases. The Center is one of only three adult liver transplant programs in the Houston area.

Based at The Methodist Hospital, the liver transplant program is a UNOS-approved program which has been extremely successful since its inception in July of 1998. The size of the program has increased steadily, and in the year 2000 is currently performing the most number of liver transplants in Houston. In addition, Methodist surgeons are among the few teams in Houston utilizing innovative techniques such as split-liver transplantation.

The Liver Center expands the services currently offered by the Methodist Transplant Center to include the entire spectrum of medical and surgical treatments for liver and biliary tract disease, including education and screening.

Dr. Ghobrial has been recruited to the Methodist Hospital, Houston, Texas as Director of the Comprehensive Liver Center; Director of Liver Transplantation ; Director of the Immunobiology Research Center and Professor of Surgery, Weill Cornell University School of Medicine, he will begin his position, March 1, 2008


 After earning his MD degree from Cairo University Medical School in Egypt, he completed his internship at the Massachusetts General Hospital in Boston and his surgical residency at the University of Texas/M. D. Anderson Cancer Center in Houston. His clinical fellowship in multi-organ transplantation was conducted at the Dumont-UCLA Liver Transplant Center. During his surgical training, Dr. Ghobrial completed two postdoctoral basic science research fellowships in immunology at Harvard University and the University of Texas Medical School at Houston. He went on to receive his PhD in immunology from the Graduate School of Biomedical Sciences at the University of Texas.

As a researcher, Dr. Ghobrial maintains an active laboratory for basic science studies which focus on transplant immunomodulation and the inhibition of chronic rejection by indirect presentation of class I major histocompatibility (MHC) molecules and co-stimulatory pathways in allograft recipients. His clinical research interests include partial liver grafting, adult-to-adult living donor liver transplantation, immunosuppression and transplantation for hepatitis C. He is the principal or co-investigator of NIH-sponsored basic and clinical research studies, as well as multiple clinical trials associated with liver transplantation.  Dr. Ghobrial is the author or co-author on well over 100 journal articles and book chapters. He lectures extensively on a variety of topics related to liver transplantation in both national and international forums, and has received multiple honors and awards. Currently, he is an active member of multiple transplantation and surgical societies, additionally, the American Surgical Association and is a fellow of the Royal College of Surgeon of Edingburgh.